Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas
نویسندگان
چکیده
منابع مشابه
Distinct transcriptional responses of lymphatic endothelial cells to VEGFR-3 and VEGFR-2 stimulation
Vascular endothelial growth factors (VEGFs) and their receptors play crucial roles in the formation of blood and lymphatic vessels during embryogenesis, and also under pathologic conditions in the adult. Despite intensive efforts over the last decades to elucidate the precise functions of VEGFs, transcriptional responses to VEGF receptor stimulation are still not fully characterized. To investi...
متن کاملVEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells Short title for running head: VEGFR-3+ lymphatic/vascular endothelial precursors
Human CD133(AC133)+CD34+ stem and progenitor cells derived from fetal liver and bone marrow, and blood incorporate a functional population of circulating endothelial precursor cells. Vascular endothelial growth factor receptor 3 (VEGFR-3) regulates cardiovascular development, and physiological and pathological lymphangiogenesis and angiogenesis. However, the origin of VEGFR-3+ endothelial cells...
متن کاملCD34+VEGFR-3+ progenitor cells have a potential to differentiate towards lymphatic endothelial cells
Endothelial progenitor cells (EPCs) play an important role in postnatal neovascularization. However, it is poorly understood whether EPCs contribute to lymphangiogenesis. Here, we assessed differentiation of a novel population of EPCs towards lymphatic endothelial cells and their lymphatic formation. CD34(+) VEGFR-3(+) EPCs were isolated from mononuclear cells of human cord blood by fluorescenc...
متن کاملVEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells.
Human CD133 (AC133)(+)CD34(+) stem and progenitor cells derived from fetal liver and from bone marrow and blood incorporate a functional population of circulating endothelial precursor cells. Vascular endothelial growth factor receptor 3 (VEGFR-3) regulates cardiovascular development and physiological and pathological lymphangiogenesis and angiogenesis. However, the origin of VEGFR-3(+) endothe...
متن کاملSuppression of lymphangiogenesis in human lymphatic endothelial cells by simultaneously blocking VEGF-C and VEGF-D/VEGFR-3 with norcantharidin.
Lymph node metastasis of tumors is a crucial early step in the metastatic process. Tumor lymphangiogenesis plays an important role in promoting tumor metastasis to regional lymph nodes. Norcantharidin (NCTD) has been reported to possess potent anti-angiogenesis and antitumor properties in several cell lines and xenograft tumor models. However, its...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2007
ISSN: 1471-2407
DOI: 10.1186/1471-2407-7-105